DPS Pharmaceutical GC Systems - Application Notes


    Each of these Pharmaceutical Applications can be analyzed using one of the Custom GC configurations of the Series 600 Lab GC. However, all can also be analyzed using the Companion 1, or the Companion 2 Portable GC Systems.  Best of all, each of these Custom GC Systems gives the same great results. So, whether your analyzing in the Lab, or in the factory, or out in the field, you can rest easy knowing that your Pharmaceutical results will always be consistent.

Antidepressants

     Antidepressants drugs help reduce the extreme sadness, hopelessness, and lack of interest in life that are typical in people with depression. Most antidepressants are believed to work by slowing the removal of certain neurotransmitters, such as serotonin and norepinephrine, from the brain. Neurotransmitters are needed for normal brain function and are involved in the control of mood and in other responses and functions, such as eating, sleep, pain, and thinking. The DPS Antidepressants GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Antidepressants GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Amitriptyline
Trimipramide
Imipramine
Nortriptyline
Doxepin
Desipramine
Maprotyline
Clomipramine

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Antiepileptics

     Antiepileptics are anticonvulsants that belong to a diverse group of pharmaceuticals used to prevent seizures. The goal is to suppress the rapid and excessive firing of neurons that start a seizure. If the seizure can not be prevented, then a good anticonvulsant will limit the spread of the seizure within the brain and offer protection against possible brain damage. The DPS Antiepileptics GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Antiepileptics GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Valproic Acid
Ethosuximide
Methsuximide
Phensuximide
Desmethyl
Methsuximide
Mephenytoin
Ethotoin
PEMA
Phenobarbitoal
Primidone
Carbamazepine
Diphenylhydantoin

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Antihistamines

     Antihistamines are medicines that help stop allergy symptoms such as itchy eyes, sneezing and a runny nose. They work by preventing the effects of a substance called histamine. The body produces histamine in response to an allergic reaction. In some people histamine can also close up air passages of the lungs making breathing difficult. The DPS Antihistamines GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Antihistamines GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Phenylpropanolamine
Ephidrine
Pseudoephidrine
Pheniramine
Diphenhydramine
Doxylamine
Phenyltoloxamine
Methapyrilene
Chlorpheniramine
Brompheniramine
Triprolidine

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Barbiturates

     Barbiturates are sedatives which depress or slow down the body’s functions. We often refer to these drugs as tranquilizers and sleeping pills, or sometimes just as sedatives. Their effects range from calming down anxious people to promoting sleep. Both tranquilizers and sleeping pills can have either effect, depending on how much is taken. At high doses or when they are abused, many of these drugs can even cause unconsciousness and death. The DPS Barbiturates GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Barbiturates GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Ethosuximide
Barbital
Methyprylon
Aprobarbital
Butalbital
Amobarbital
Pentobarbital
Secobarbital
Glutethimide
Meprobamate
Carisoprodol
Phenobarbital
Methaqualone
Carbamazepine
Primidone
Diphenylhydantoin

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Cannabis - Medical Marijuana

     Cannabis, or medical marijuana, refers to the use of constituents of cannabis, THC and other cannabinoids, as a physician-recommended form of medicine therapy. The medicinal value of cannabis has several well-documented beneficial effects, such as the amelioration of nausea and vomiting, stimulation of hunger in chemotherapy and AIDS patients, lowered intraocular eye pressure for treating glaucoma, as well as general analgesic pain relieving effects. DPS has configured the Cannabis GC Systems with the sensitive FID detector to identify the major cannabinoids THC, CBD, and CBN as well as identifying and determining Terpene concentrations. For extra product safety we can add our ultra-sensitive BCD Detector to analyze for Pesticide contamination at the same time. The Series 600 GC is for analyses in the lab, or use the Portable Companion 2 GC System for analyses in the growing fields, or at the dispensary. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Cannabis GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
CBD
THC
CBN
Terpenes
etc.

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CAN Method 100

Method for the determination of Cannabinoids and Organochlorine Pesticides in Marijuana and Extracts.

Cold Medicines

     One of the most important pharmaceutical applications is the GC analysis of basic drugs. This broad category encompasses a variety of stimulants, and sedatives, which includes cold medicines. Each of these drugs has rigid specifications placed on the purity of the products formulation, which we as consumers appreciate most when we feel the onset of the common cold. The DPS Cold Medicines GC Systems are designed with safety in mind to check the drug purity throughout the manufacturing process. Each GC System is configured with the latest high resolution capillary column and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Cold Medicines GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Phenylpropanolamine
Phenylephrine
Guaifensin
Pheniramine
Phenyltoloxamine
Chlorpheniramine
Brompheniramine
Dextromethorphan
Pyrilamine
Codeine
Hydrocodone

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Residual Solvents

     There is no way around it, residual process solvents are commonly detected in pharmaceutical products. Consequently, many government agencies have made it mandatory to measure the residual solvents for the release testing of all active pharmaceutical ingredients. Analyses are also routinely performed on process intermediates used during the drug synthesis. The help with these regulations the DPS Pharmaceutical Solvents GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC System for analyses right where the samples are taken. The fast heating and rapid cooling column oven in every DPS GC vastly increases your sample throughput. The fully integrated Pharmaceutical Solvents GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
Methanol
Methylene Chloride
Acetonitrile
trans-1,2-Dichloroethylene
cis-1,2-Dichloroethylene
Tetrahydrofuran
Cyclohexane
Methylcyclohexane
1,4-Dioxane
Toluene
Dimethyl Sulfoxide
o-Xylene

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Steroids

     Steroids, androgenic and anabolic, are a class of synthetic drugs related to male sex hormones. Androgenic steroids are used to increase masculine characteristics when the body produces abnormally low amounts of testosterone, such as delayed puberty, some types of impotence, and body wasting, as in patients with AIDS. Anabolic steroids, on the other hand, are used by athletes to enhance performance and also to improve physical appearance. Abuse of anabolic steroids can lead to serious health problems including, liver tumors, cancer, jaundice, fluid retention, high blood pressure, and increased cholesterol. The DPS Steroids GC Systems are configured with the latest designed high resolution capillary columns and the sensitive FID detector to quickly detect these compounds. The Series 600 GC is for analyses in the lab, or use the Portable Companion 1 GC Systems for analyses right where the samples are taken. The fully integrated Steroids GC Analyzer Systems are small and lightweight and all Pharmaceutical DPS systems are modular for expandability, upgrades, and easy service.
Example Compounds:
5-Androstene-3b,17b-diol
17a-Methyl-5-5androstene-3b,17b-diol
5a-Androstan-17b-ol-3-one
19-Nortestosteronel
17a-Methylandrostan-17b-ol-3-one
Mesterolone
Testosterone
17a-Methyltestosterone
1-Dehydrotestosterone
1-Dehydro-17a-methyl testosterone
Bolasterone
Oxymethalone
19-Nortestosterone-17-acetate
Testosterone Propionate
Fluoxymesterone
4-Chlorotestosterone-17-acetate
Testosterone-17b-cypionate
1-Dehydotestosterone Benzoate
1-Dehydrotestosterone Undecylenate

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